According to a study released on Sunday, statins had a greater impact on cardiovascular health than six supplements that individuals frequently take for heart health. According to Themacforums study Don’t Bother with Dietary Supplements for Heart Health, Study Says.

Some people think that taking common dietary supplements like red yeast rice, fish oil, garlic, cinnamon, and turmeric can lower their “bad” cholesterol. Low-density lipoproteins, or LDL, are referred to as “bad” cholesterol in the medical world and are responsible for the formation of fatty deposits in arteries.

The heart needs blood and oxygen to function, and fatty deposits can obstruct those flows. An obstruction like this can cause a heart attack or stroke.

In this study, which was simultaneously published in the Journal of the American College of Cardiology and presented at the American Heart Association’s Scientific Sessions 2022, researchers compared the effects of these specific supplements to those of a low dose of the cholesterol-lowering drug statin or a placebo, which has no effect.

In a randomized, single-blind clinical trial involving 190 persons without a history of cardiovascular disease, the researchers did this comparison. Participants in the study ranged in age from 40 to 75. For 28 days, separate groups were given rosuvastatin, a low-dose statin, a placebo, fish oil, cinnamon, garlic, turmeric, plant sterols, or red yeast rice.

Comparing the statin to the supplements and placebo, the statin dramatically reduced LDL.

After 28 days on a statin, the average LDL reduction was close to 40%. Additionally, statin was helpful in lowering blood triglycerides by 19% and total cholesterol, which fell by an average of 24%.

None of the supplement users saw a substantial reduction in LDL cholesterol, total cholesterol, or blood triglycerides; their outcomes were comparable to those of placebo users. While all the groups experienced similar side effects, those who consumed red yeast rice or plant sterols experienced statistically more issues.

Don’t Bother with Dietary Supplements for Heart Health, Study Says

According to to study co-author Dr. Karol Watson, professor of medicine/cardiology and co-director of the UCLA Program in Preventive Cardiology, “We designed this study because many of us have had the same experience trying to recommend evidence-based therapies that reduce cardiovascular risks to patients and then having them say “no thanks, I’ll just try this supplement” “We wanted to prove what we already knew and show it in a rigorous way,” the researchers said of their very strict, randomized, controlled trial study design.

Patients frequently are unaware that dietary supplements aren’t tested in clinical trials, according to Dr. Steven Nissen, a cardiologist, researcher, and study co-author at the Cleveland Clinic. These supplements are what he refers to as “21st-century snake oil.”

The Dietary Supplement and Health Education Act of 1994 severely curtailed the US Food and Drug Administration’s capacity to control supplements in the country. The FDA does not need to approve dietary supplements before they may be sold, unlike pharmaceutical medicines which must be demonstrated to be safe and effective for their intended use before a company can market them.

Don’t Bother with Dietary Supplements for Heart Health, Study Says. The FDA cannot control them before they are on the market and have been shown to be dangerous.

Patients think studies have been done and that they are as effective as statins and can save them since they are natural, but Nissen noted that neither safety nor effectiveness comes from being natural.

Rosuvastatin manufacturer AstraZeneca provided an unrestricted grant for the study’s funding. According to the report, the corporation had no input into the methodology, data analysis, or discussion of the therapeutic implications.

The study’s sample size was limited, and the researchers noted that the 28-week study period might not accurately reflect the effects of supplements when used for longer periods of time.

Private label that fits pharma brands

The Council for Responsible Nutrition, a trade group for the dietary supplement sector, issued a statement on Sunday stating that “supplements are not meant to substitute pharmaceuticals or other medical treatments.”

The group’s senior vice president for scientific and regulatory affairs, Andrea Wong, said in a statement that dietary supplements are not meant to be quick solutions and that four-week research may not disclose all of their impacts.

The work will be beneficial, according to Dr. James Cireddu, an invasive cardiologist and the medical director of the University Hospitals Harrington Heart & Vascular Institute at University Hospitals Bedford Medical Center.

Cireddu, who was not involved in the study, stated, “They did a fantastic job gathering data and looking at the consequences. It’s likely to strike a chord with them. I frequently get inquiries about vitamins. This provides good proof, in my opinion.

Despite not participating in the study, Dr. Amit Khera, chair of the AHA Scientific Sessions programming committee, said he thought it was crucial to include this research in this year’s presentations.

“I care for people every day and ask them things like these. According to Khera, a professor and the director of preventive cardiology at UT Southwestern Medical Center, patients frequently inquire about supplements that can be taken instead of or in addition to statins. “I believe it is incredibly important to help inform people about the value, or in this case the lack of value, for some of these supplements for cholesterol-lowering if you have good quality evidence and a properly done study,” says the author.


Statins have been researched in more than 170,000 individuals over the course of more than 30 years, he claimed. Studies consistently demonstrate that statins reduce risk.

We know statins work, which is wonderful news, Khera said. That does not imply that they are faultless. Even though they are not necessary for everyone, we know they are effective for those who are at greater risk. Make sure it works if you’re going to try something different.

Don’t Bother with Dietary Supplements for Heart Health, Study Says. He claimed that misinformation about supplements is common online.

“I believe that people are constantly seeking out something that is ‘natural,’ but you know, there are a lot of problems with that language, and the most crucial question is: Do they actually work? This study does that, Khera continues. “It’s crucial to consider whether you are taking a proven medication, and if not, whether you are substituting it for a known treatment. It’s a serious issue.